Santo Domingo has a population of 45,476, making it the 43rd largest place we list in Cuba. It is in Villa Clara Province.
Santo Domingo holds 0.42% of Cuba's 10,892,659 people. Havana, the largest place we list there, is 48 times its size. Twenty years earlier the World Gazetteer recorded 45,476, almost unchanged.
The 2005 figure comes from the World Gazetteer archive restored on this site. The two sources may draw the settlement's boundary differently, so treat the change as indicative rather than exact. Why figures differ.
Nearby in size
| Place | Region | Population |
|---|---|---|
| Baracoa | Guantánamo Province | 48,362 |
| Jovellanos | Matanzas Province | 47,164 |
| Bauta | Artemisa | 45,768 |
| Cabaiguán | Sancti Spíritus Province | 44,515 |
| Regla | Havana | 44,431 |
| San Germán | Holguín Province | 43,892 |
Figures are the latest available in GeoNames (CC BY 4.0), which draws on national censuses of varying dates — treat them as recent, not same-year. Country totals are UN World Population Prospects 2024 (medium variant) where the UN lists the country separately; the handful it reports under a parent state keep a GeoNames figure and are marked as such. Sources & method.